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関連する概念動画

Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
358
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
369
Cancer Survival Analysis01:21

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Updated: Jul 1, 2025

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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がん の 後 の 閉経 の 管理

Martha Hickey1, Partha Basu2, Jenifer Sassarini3

  • 1Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne and the Royal Women's Hospital, Melbourne, VIC, Australia.

Lancet (London, England)
|March 8, 2024
PubMed
まとめ

癌を生き延びた人は しばしば 深刻な閉経症状に直面し 生活の質に 影響を及ぼします ホルモン療法の安全性とがん患者の非ホルモン治療の選択肢を考慮して,効果的な管理戦略が必要である.

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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科学分野:

  • 腫瘍学
  • 婦人科
  • 閉経 管理

背景:

  • 毎年何百万人もの女性が がんと診断され 世界中で最も多いのが乳がんです
  • 癌の生存率の向上により,早発性卵巣不全 (POI) や早期更年期などの長期的治療効果を 経験する女性が増加します.
  • がん治療による更年期症状は 自然な更年期より重症で 性機能障害,睡眠障害,気分障害,生活の質の低下などがあります

研究 の 目的:

  • 癌の生存者における 更年期症状の診断と管理における課題を検討する.
  • 閉経期ホルモン療法 (MHT) と癌患者の非ホルモン治療の有効性と安全性を評価する.
  • 患者中心のケアモデルを 改善する必要性を強調するためです

主な方法:

  • 癌の生存者の更年期症状管理に関する現在の文献のレビュー.
  • 閉経期ホルモン療法 (MHT) と非ホルモン療法に関する証拠の分析
  • 診断の課題とケア提供モデルの議論

主要な成果:

  • 癌の生存者の閉経症状は重症で,癌に関連する症状と重複し,診断を複雑にします.
  • MHTは血管運動症状に効果があり,多くのがん患者にとって一般的に安全です.
  • 非ホルモンおよび非薬学的治療は有望ですが,特に若い女性および乳がん以外の診断では,証拠は限られています. 排尿器系の症状には Vaginal estrogenは安全ですが 排尿器系以外の選択肢はほとんどありません

結論:

  • 癌後の更年期症状の管理は,治療の安全性と有効性を慎重に検討する必要があります.
  • 非ホルモン療法に関する証拠には大きなギャップがあり,さらなる研究が必要である.
  • 改善され,集中され,患者に焦点を当てたケアモデルは, 更年期を体験している癌の生存者の満たされていないニーズに対処するために不可欠です.