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Updated: Jul 14, 2026

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
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Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

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水力学測定とメチルTROSY NMRを使用して600 kDaのDegPプロテアースケージ複合体内のホスト-ゲストの相互作用を探求する

Robert W Harkness1,2,3,4, Huaying Zhao5, Yuki Toyama1,2,3,4

  • 1Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Canada.

Journal of the American Chemical Society
|March 13, 2024
PubMed
まとめ

DegPプロテアゼ-チャペロンは,そのケージ内の展開されたクライアントタンパク質を安定させ,基板結合時に活性化します. このダイナミックな機械は 細菌のタンパク質ホメオスタシスと ストレス下での生存に不可欠です

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Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics

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関連する概念動画

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...