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関連する概念動画

Development of the Heart01:27

Development of the Heart

934
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
934
Chambers of the Heart01:16

Chambers of the Heart

4.5K
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
4.5K
Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

10.7K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
10.7K
Anatomy of the Heart01:27

Anatomy of the Heart

108.7K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
108.7K

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関連する実験動画

Updated: Jul 1, 2025

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells
08:56

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells

Published on: September 15, 2021

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空間 的 に 組織 さ れ た 細胞 群 が 発達 し て いる 人 の 心臓 を 形成 する

Elie N Farah1, Robert K Hu1, Colin Kern2

  • 1Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.

Nature
|March 14, 2024
PubMed
まとめ

研究者は人間の心臓細胞の 発達と組織をマッピングしました これは心臓の細胞コミュニティが 心臓の機能や病気の洞察に 重要な構造を形成していることを示しています

さらに関連する動画

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

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Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
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Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Published on: October 7, 2016

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関連する実験動画

Last Updated: Jul 1, 2025

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells
08:56

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells

Published on: September 15, 2021

9.4K
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

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Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
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Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

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科学分野:

  • 発達生物学
  • 心血管研究
  • 単細胞ゲノム

背景:

  • 機能には心臓の形が不可欠ですが,発達中の心臓細胞の空間的調整はよくわかっていません.
  • 心臓の形質変異を理解することは 生まれながらの心疾患の治療と 再生療法の開発の鍵です

研究 の 目的:

  • 人間の心臓の発達過程で心臓細胞の種類を特定し,空間的にマッピングする.
  • 機能的なコミュニティと構造に心臓細胞の組織を解明する.
  • 心臓細胞の空間的組織と特異性を 制御する信号経路の発見

主な方法:

  • 統合された単細胞RNAシーケンシング (scRNA-seq) と高解像度マルチプレックスエラーロバスト光 in situハイブリッド化 (MERFISH).
  • 条件付きマウスモデルとヒト多能幹細胞システムをin vitroで利用した.
  • 特定された心臓細胞コミュニティ内の細胞間の相互作用を分析した.

主要な成果:

  • 発達中の人間の心臓の心臓細胞タイプのアイデンティティと空間的組織が解明された.
  • 特定の細胞コミュニティ内の亜集団に心臓細胞のタイプ特異化を発見した.
  • 室内心筋細胞のサブ集団の複雑な分層組織を明らかにし,形態変異を指揮する多細胞信号伝達経路を特定した.

結論:

  • 心臓の細胞の種類と その空間的組織を 詳細にマッピングすることで 人間の心臓の発達に関する 根本的な洞察が得られます
  • 細胞コミュニティとシグナル伝達経路の理解は 構造的な心臓病の新たな視点を提供します
  • この発見はヒトの心臓修復と再生医療の 組織工学の進歩を支えています