関連する実験動画

Updated: Jul 1, 2025

Preparation of Single-Cell Suspension of Mouse Thymic Epithelial Cells and Staining of Intracellular Molecules for Flow Cytometric AnalysisMechanisms
09:41

Preparation of Single-Cell Suspension of Mouse Thymic Epithelial Cells and Staining of Intracellular Molecules for Flow Cytometric AnalysisMechanisms

Published on: July 26, 2024

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AIREはZ-DNAに頼って,胸膜T細胞の受容性を標識する

Yuan Fang1,2, Kushagra Bansal3, Sara Mostafavi4,5

  • 1Department of Immunology, Harvard Medical School, Boston, MA, USA.

Nature
|March 14, 2024
PubMed
まとめ

自己免疫調節タンパク質 (AIRE) は,DNA二重鎖の断裂とバランスの取れたプロモーターを促進するZ-DNAとNFE2-MAFモチーフを認識することによって,遺伝子を標的にします. このメカニズムは,AIREを誘導することで,T細胞の耐性を高めます.

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