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Updated: Jul 1, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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選択的分子接着剤によって制御されるコンパクトタンパク質の分解タグの継続的な進化

Jaron A M Mercer1,2,3, Stephan J DeCarlo1,2,3, Shourya S Roy Burman4,5

  • 1Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|March 14, 2024
PubMed
まとめ

研究者らは,分子接着剤技術を用いて,小さな特定のタンパク質デグロン (SD40) を開発した. この突破により 固有のタンパク質の濃度が 精密に制御され 現在の分解手段の限界を 克服できます

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