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Updated: Jun 30, 2025

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

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プロテオリスティックに安定したチオペプチドのデノボ発見のためのコンパクトな再プログラムされた遺伝子コード

Alexander A Vinogradov1, Yue Zhang1, Keisuke Hamada2

  • 1Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|March 16, 2024
PubMed
まとめ

この研究は,代謝的に安定したチオペプチドを発見するための再プログラムされたmRNA表示プラットフォームを導入します. この新しい方法は非タンパク質性アミノ酸を用いており,薬剤発見の可能性を高めています.

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