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Updated: Jun 30, 2025

A Model to Simulate Clinically Relevant Hypoxia in Humans
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Published on: December 22, 2016

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低対高酸素目標とCOVID-19における生命維持装置なしの生存日:HOT-COVIDランダム化臨床試験

Frederik M Nielsen1,2, Thomas L Klitgaard1, Martin Siegemund3

  • 1Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.

JAMA
|March 19, 2024
PubMed
まとめ

集中治療室での重度の低酸素症のCOVID-19患者の酸素濃度を下げることで,結果が改善されました. 90mmHgと比較して60mmHgのPao2をターゲットにすると,生命維持装置なしで生き延びる日数が増加しました.

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
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The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
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A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
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The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
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