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Updated: May 2, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
09:29

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

8.5K

老化中のヒトの神経細胞とオリゴデンドロサイトにおける体変異パターンの対比

Javier Ganz1, Lovelace J Luquette2, Sara Bizzotto3

  • 1Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell
|March 19, 2024
PubMed
まとめ

脳の細胞の老化は 独特の体内の変異パターンを伴います オリゴデンドロサイトはニューロンよりも単一核酸変異を早く蓄積し,ゲノム位置によって異なる変異が起こり,変異を引き起こす過程が異なることを示唆する.

キーワード:
年老化脳がん脳の障害グリア細胞グリオマグリオマゲネシスオリゴデンドロサイト前駆細胞オリゴデンドロサイトソマティック変異

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