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NusGの補償的な進化は,薬剤耐性M.結核の適性を改善する

Kathryn A Eckartt1, Madeleine Delbeau2, Vanisha Munsamy-Govender1

  • 1Laboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.

Nature
|March 21, 2024
PubMed
まとめ

薬剤耐性 結核 (TB) は 増大 し て いる 脅威 です. 研究者らは,転写因子NusGによって引き起こされる過剰なRNAポリメラーゼの停止が,Mycobacterium tuberculosisにおけるリファムピシン耐性のフィットネスコストを引き起こすことを発見した.

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