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Updated: Jun 30, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

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非リボソームペプチド合成酵素の進化に触発された工学

Kenan A J Bozhüyük1,2,3, Leonard Präve1,2, Carsten Kegler1,2

  • 1Max Planck Institute for Terrestrial Microbiology, Department of Natural Products in Organismic Interactions, 35043 Marburg, Germany.

Science (New York, N.Y.)
|March 21, 2024
PubMed
まとめ

研究者は新しい再結合戦略を用いて,細菌の非リボソームペプチド合成酵素 (NRPS) を設計した. このアプローチは,プロテアソーム阻害剤を含む複雑なNRPS由来分子のモジュール組成を可能にします.

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Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence11:51

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