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Updated: Jun 30, 2025

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
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Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

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超分子免疫細胞死亡誘発剤によるがん治療の強化:ライソソーム標的型NIR光活性化ルテニウム (II) メタラサイクル

Le Tu1, Chonglu Li1,2, Qihang Ding3

  • 1National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.

Journal of the American Chemical Society
|March 21, 2024
PubMed
まとめ

Ru1105という新しいルテニウム (II) メタラサイクルは,深く根付いた腫瘍における免疫細胞死 (ICD) を効果的に引き起こす. この近赤外線活性化剤は 副作用の少ない抗腫瘍免疫力を高め 新しいがん治療法として有望です

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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