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Updated: Jun 30, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

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ペプチド抗生物質コラミシンは,β-ヘアピンのような構造を採用し,キナーゼCOMGによって無活性化されます

Sebastian Adam1, Franziska Fries1,2,3, Alexander von Tesmar1

  • 1Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Campus E8 1, 66123 Saarbrücken, Germany.

Journal of the American Chemical Society
|March 21, 2024
PubMed
まとめ

新しいキナーゼであるComGは,抗生物質コラマイシンをリン酸化によって無効化し,宿主に対する耐性を授与する. この発見は 耐性のあるグラム陰性細菌に対する 新しい抗生物質の開発に 極めて重要です

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