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Updated: Jun 29, 2025

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DCAF5をターゲットにすることで,SWI/SNFを安定させることで,SMARCB1変異がんを抑制する

Sandi Radko-Juettner1,2, Hong Yue3,4, Jacquelyn A Myers1

  • 1Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.

Nature
|March 28, 2024
PubMed
まとめ

がんにおけるSMARCB1腫瘍抑制機能の喪失は,突然変異によって直接引き起こされるのではなく,DCAF5を退廃させるSWI/ SNF複合体によって引き起こされる. DCAF5をターゲットにすることで,SWI/SNF機能を回復させることで,がん状態を逆転させることができます.

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