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Updated: Jun 29, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

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多薬剤薬剤設計のための柔軟な基架ベースの化学情報学アプローチ

Zhangcheng Chen1, Jing Yu1, Huan Wang2

  • 1Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

Cell
|March 29, 2024
PubMed
まとめ

中枢神経系 (CNS) の疾患に対する多剤薬の設計は困難です. 新しいフレキシブルなエスカフォルドベースの化学情報学アプローチ (FSCA) は,複数のターゲットへの関与のための特定の結合姿勢を利用することで,合理的な薬物設計を可能にします.

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