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Updated: Jun 29, 2025

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

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Published on: October 19, 2013

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BRCC3 血管の滑らかな筋肉細胞におけるALK2の調節:肺高血圧への関与

Hui Shen1, Ya Gao1, Dedong Ge1

  • 1Department of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Institute of Cardiovascular Disease, Yangzhou Key Lab of Innovation Frontiers in Cardiovascular Disease, China (H.S., Y.G., D.G., M.T., Q. Yin, Z.L., X.L., Z.C., Y.Y., Z.Z., K.G.).

Circulation
|April 1, 2024
PubMed
まとめ

BRCC3によるALK2のデウビキチン化により,肺動脈高血圧 (PAH) に重要なBMPとTGF-βのシグナル伝達が再バランスされます. BRCC3の機能を回復させることで,血管の恒常性を促進することで,PAHを緩和します.

キーワード:
BRCC3タンパク質アクティブリン受容体のようなキナーゼ-2骨の形態遺伝タンパク質肺動脈高血圧

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