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Updated: Jun 29, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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Published on: March 2, 2014

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DNAポリメラーゼ・ガンマの祖先アレルは,抗ウイルス耐性を変化させる

Yilin Kang1, Jussi Hepojoki2,3, Rocio Sartori Maldonado1

  • 1Stem Cell and Metabolism Research Program Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Nature
|April 3, 2024
PubMed
まとめ

ミトコンドリアDNAポリメラーゼガンマ (POLG1) 欠陥は抗ウイルス防御を弱め,ミトコンドリア疾患における疾患の多様性を引き起こします. p.W748Sの変種はミトコンドリアDNAの安定性を損なっており,免疫不全や神経および肝臓の問題を引き起こします.

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Translesion DNA Polymerases02:10

Translesion DNA Polymerases

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
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Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
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