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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

9.2K
Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
9.2K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

394
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
394
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Alveoli and Alveolar Ducts01:26

Alveoli and Alveolar Ducts

2.4K
The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...
2.4K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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関連する実験動画

Updated: Jun 29, 2025

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
07:40

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

Published on: February 21, 2025

488

エピテリア 細胞 が 喘息 で 混ざっ て いる

Jeffrey M Drazen1, Jeffrey J Fredberg1

  • 1Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.

Science (New York, N.Y.)
|April 4, 2024
PubMed
まとめ

呼吸道が狭くなり,上皮細胞が外出する. このプロセスは呼吸道炎症を促進し,呼吸器疾患に寄与します.

科学分野:

  • 肺医学
  • 細胞生物学
  • 免疫学

背景:

  • 呼吸道炎症は 喘息のような呼吸器疾患の特徴です
  • エピセルの細胞は 呼吸道を覆うバリアを形成し 免疫反応に役割を果たします

研究 の 目的:

  • ブロンココンストリクションと上皮細胞挤出との関連を調査する.
  • 呼吸道炎症に エピテリア細胞の流出がどのように影響するかを理解するためです

主な方法:

  • 呼吸器の滑らかな筋肉の収縮を in vitro モデルで調べました
  • 顕微鏡技術を使って 皮質細胞の行動を観察する
  • 細胞流出に対する炎症マーカーの評価

主要な成果:

  • ブロンココンストリクションは,重要な上皮細胞挤出を誘導することが観察されました.
  • 挿出された上皮細胞は,炎症促進媒介体を放出することが判明しました.
  • この流出過程は,呼吸道炎症の増加と直接相関していました.

結論:

  • 上皮細胞の挤出は, 支柱管収縮の直接的な結果です.

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Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment
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Author Spotlight: Modeling Human Airway Remodeling and Viral Responses Using Isogenic Epithelial, Endothelial, and Immune Cells
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Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment
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  • この細胞反応は呼吸器の炎症を悪化させ 呼吸器の病理学における新しいメカニズムを 明らかにします