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Updated: Jun 29, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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Published on: December 23, 2016

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サルファタゼ誘導による抗腫瘍性Supra- PROTACのインシット製剤

Ninglin Chen1,2, Zeyu Zhang1, Xin Liu1

  • 1Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.

Journal of the American Chemical Society
|April 5, 2024
PubMed
まとめ

研究者らは,がん細胞内に組み立てられるSupra-PROTACを開発し,がん治療の強化のために標的タンパク質の分解を改善しました. この革新的なアプローチにより 薬の投与と有効性が向上し バイオセーフティが保たれています

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Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme...
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