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Updated: Jun 28, 2025

Live Imaging Assay for Assessing the Roles of Ca2+ and Sphingomyelinase in the Repair of Pore-forming Toxin Wounds
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Live Imaging Assay for Assessing the Roles of Ca2+ and Sphingomyelinase in the Repair of Pore-forming Toxin Wounds

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ROSに依存するS-パルミトイライション活性化剤は,割れ,無傷のガスダーミンD

Gang Du1,2, Liam B Healy3,4, Liron David5,6,7

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. gdu@crystal.harvard.edu.

Nature
|April 10, 2024
PubMed
まとめ

ガスダーミンD (GSDMD) はパルミトイロ化されていて,これは熱死時に毛穴形成に不可欠な変化です. この可逆パルミトイレーションは,GSDMDの活性化に重要なスイッチとして作用し,分裂が唯一のトリガーであるという以前の概念に異議を唱えます.

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