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Updated: Jun 28, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Published on: June 9, 2017

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リガンドの有効性はμ-オピオイド受容体の構成動態を調節する

Jiawei Zhao1,2,3, Matthias Elgeti4,5, Evan S O'Brien6

  • 1State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.

Nature
|April 10, 2024
PubMed
まとめ

薬がμ-オピオイド受容体 (μOR) とどのように相互作用するかを理解することは,痛み管理の鍵です. この研究は,リガンド特異の受容体変化と,薬剤の効能とGタンパク質結合に影響を与える明確な形状を明らかにした.

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