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Updated: Jun 28, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
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Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

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FOXO1は,CAR T細胞におけるメモリプログラミングの主調節体である

Alexander E Doan1, Katherine P Mueller2,3,4, Andy Y Chen5,6,7

  • 1Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|April 10, 2024
PubMed
まとめ

転写因子FOXO1は記憶を促進し,キメリック抗原受容体 (CAR) T細胞の疲労を防ぐ. 過剰発現したFOXO1は,CAR T細胞の持続性と抗腫瘍活性を高め,がん免疫療法の結果を改善します.

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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

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