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Updated: Jun 28, 2025

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

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糖分解性代謝物は,BRCA2による"二重ヒット"腫瘍抑制をバイパスする

Li Ren Kong1, Komal Gupta2, Andy Jialun Wu3

  • 1Cancer Science Institute of Singapore, Singapore 117599, Singapore; NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore 117599, Singapore; MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK; Department of Pharmacology, National University of Singapore, Singapore 117600, Singapore.

Cell
|April 12, 2024
PubMed
まとめ

メチルグリオキサル (MGO) は一時的にBRCA2を不活性化させ,2つのヒットがんモデルをバイパスします. この代謝メカニズムは,MGOと癌の発生における特定の変異シグネチャーを結びつける.

キーワード:
DNA 修復と複製乳がん遺伝子BRCA2ガンゲノム癌の代謝環境発がん遺伝子と環境の相互作用グリコリスメチルグリオキサール変異シグネチャー腫瘍抑制

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