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Updated: May 6, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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統合的空間分析により,多層構造の膠芽細胞腫が明らかになった

Alissa C Greenwald1, Noam Galili Darnell1, Rouven Hoefflin2

  • 1Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Cell
|April 23, 2024
PubMed
まとめ

この研究は 多様な膠原癌細胞状態が 腫瘍内で組織化されていることを明らかにしています 細胞の組織と腫瘍の構造に影響を与える 重要な要因として機能します

キーワード:
グリオブラストーマグリオマ低酸素腫瘍内異質性空間プロテオミクス空間トランスクリプトミクス

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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