関連する実験動画

Updated: Jun 28, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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アラニル-tRNA合成酵素 (AARS1) は,乳酸センサーであり,乳酸トランスフェラーゼで,p53を乳酸化し,腫瘍形成に寄与する

Zhi Zong1, Feng Xie2, Shuai Wang2

  • 1The First Affiliated Hospital, the Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.

Cell
|April 23, 2024
PubMed
まとめ

アミノアシル- tRNA合成酵素1 (AARS1) は乳酸センサーとして作用し,がん細胞におけるライシン乳化を媒介する. このp53のようなタンパク質の改変は,その機能を阻害し,腫瘍の成長を促しますが,β-アラニンによって逆転することができます.

キーワード:
AARS1 についてLLPS についてアラニル-tRNA合成酵素1乳酸ラクチレーションラクチルトランスフェラーゼ液体-液体相分離p53 について腫瘍の進行β-アラニン

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