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Updated: Jun 28, 2025

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
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PGE2は,腫瘍に浸透する幹細胞のようなCD8+T細胞のエフェクター拡大を制限する

Sebastian B Lacher1, Janina Dörr2, Gustavo P de Almeida3

  • 1Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Nature
|April 24, 2024
PubMed
まとめ

腫瘍に由来する前列腺素E2 (PGE2) は,がん特異のTCF1+ CD8+ T細胞の拡大と分化を阻害する. PGE2シグナル伝達を阻害すると,T細胞の機能が回復し,腫瘍の除去が促進され,新しいがん免疫療法標的となる.

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