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Updated: Jun 28, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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PGE2はIL-2シグナル伝達とミトコンドリア機能を妨害することでTIL膨張を阻害する

Matteo Morotti1,2,3, Alizee J Grimm1,2,3, Helen Carrasco Hope1,2

  • 1Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.

Nature
|April 24, 2024
PubMed
まとめ

プロスタグランジンE2 (PGE2) は,IL-2シグナル伝達を阻害することによって,腫瘍の微小環境におけるT細胞機能を損なう. PGE2を阻害すると,T細胞の膨張と抗腫瘍反応が促進され,受容細胞治療の有効性が向上する.

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