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Updated: Jun 28, 2025

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
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単細胞分析は,mTDNAの文脈依存の細胞レベルの選択を明らかにする

Anna V Kotrys1,2, Timothy J Durham1,2, Xiaoyan A Guo1,2

  • 1Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Nature
|April 24, 2024
PubMed
まとめ

ミトコンドリアDNA (mtDNA) ヘテロプラズミーのシフトは,分裂する細胞で漂流ではなく選択によって引き起こされる. 環境条件は,mtDNA変異が細胞の健康に有益であるか有害かを決定し,ヘテロプラズミーのレベルに影響を与えます.

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