チリオパシー患者の変種は,アクソネマのマイクロチューブルにおけるTUBB4Bのオーガネル特異的機能を明らかにする

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Updated: Jun 27, 2025

Purification of Tubulin with Controlled Posttranslational Modifications and Isotypes from Limited Sources by Polymerization-Depolymerization Cycles
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Purification of Tubulin with Controlled Posttranslational Modifications and Isotypes from Limited Sources by Polymerization-Depolymerization Cycles

Published on: November 5, 2020

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Daniel O Dodd1, Sabrina Mechaussier2, Patricia L Yeyati1

  • 1MRC Human Genetics Unit, MRC Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.

Science (New York, N.Y.)
|April 25, 2024
PubMed
まとめ

チューブリン同型であるTUBB4Bの特定の変異は,微小管の構造を混乱させ,センチオールとシリウム形成に影響を与えます. これはチューブリン病とシリオパシーを結びつけ,異なった同型機能を明らかにする.

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