神経内分泌 細胞 は 上部 の 呼吸道 の 保護 反応 を 起こす
Laura F Seeholzer1, David Julius1
1Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA.
Science (New York, N.Y.)
|April 26, 2024
まとめ
呼吸器の神経内分泌細胞は センチネルとして働き 水や酸のような有害な刺激を検知します ATPを放出し 呼吸器系を保護する 防御レフレクスを起こします
科学分野:
- 呼吸器の生理学
- 細胞神経科学
- エピテリア生物学
背景:
- 呼吸道神経内分泌 (NE) 細胞は,呼吸行動を調節する感覚細胞であると仮定されている.
- 健康な肺,気管,喉頭におけるそれらの正確な機能と生理学的役割はよく理解されていません.
研究 の 目的:
- 呼吸道におけるNE細胞の機能的性質と生理学的役割を調査する.
- NE細胞が有害な刺激に どのように反応し 保護的反射を起こすかを決定する.
主な方法:
- ネズミのNE細胞の生理学的性質の特徴化
- 吸入された刺激 (水,酸) に対するNE細胞の感受性の評価
- アデノシン5'-トリフォスファート (ATP) の放出とピュリノ受容体の活性化を含むシグナル伝達経路の分析
主要な成果:
- 肺,気管,喉頭にあるネズミのNE細胞は,独特の生体物理的特性を表しています.
- トラクエと喉のNE細胞は水と酸に敏感です.
- これらのNE細胞はATPを放出し 感覚神経細胞を活性化し 飲み込みや吐き出したりといった 保護反応を起こすのです
結論:
- 呼吸道NE細胞は 重要な分子と生体学的多様性を表しています
- NE細胞は 害のある刺激を検知し 生まれながらの呼吸道防衛機構を活性化します
- NE細胞からのATP媒介のシグナリングは,保護性呼吸反射の開始に不可欠です.
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