身体 の 炎症 反応 を 調節 する 体 と 脳 の 循環
Hao Jin1,2,3,4, Mengtong Li5,6,7, Eric Jeong5,6,7
1Zuckerman Mind Brain Behavior Institute, Howard Hughes Medical Institute, Columbia University, New York, NY, USA. hao.jin@NIH.gov.
Nature
|May 1, 2024
まとめ
体と脳の軸は 辺縁の炎症を ヴァーガルニューロンで脳と結びつけることで 免疫反応を調節します この神経免疫回路を活性化することで 脳は有害な炎症反応を制御し 抑制することができます
科学分野:
- 神経免疫学
- 生理学
背景:
- 身体と脳の軸は,代謝と栄養状態を含む生理学的プロセスの主要な調節器です.
- 臓器の働きを感知し 制御する役割が 浮き彫りにされています
研究 の 目的:
- 外部からの攻撃に対する 免疫反応の調節における 身体-脳軸の役割を調査する.
- 神経回路と脳の介した免疫調節の仕組みを特定する.
主な方法:
- 神経免疫軸の成分を特定するための単細胞RNA配列解析
- 免疫反応中の神経活動の観察のための機能的イメージング.
- 特定の神経回路を 沈黙させたり 活性化させたりする 遺伝子操作です
主要な成果:
- 辺縁の免疫攻撃は 身体と脳の軸を活性化し ヴァーガルニューロンを介して脳に信号を送ります
- 脳は周辺の炎症と抗炎症反応を 活発に調節しています
- この回路の遺伝的静止は 制御不能な炎症につながり 活性化により 神経制御が可能になります
結論:
- 身体と脳の軸は 免疫反応の調整に不可欠です
- この神経免疫回路をターゲットにすることで 炎症や自己免疫疾患の 治療の可能性が生まれます
- 脳が誘発する免疫反応の調節は 炎症を抑制し 抗炎症状態を促進します
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