父の微生物群の乱れが子孫の健康に影響する

Ayele Argaw-Denboba¹, Thomas S B Schmidt², Monica Di Giacomo¹

¹European Molecular Biology Laboratory (EMBL), Epigenetics & Neurobiology Unit, Rome, Italy.

Nature

|May 1, 2024

まとめ

親の腸内微生物群の障害は子孫の健康に影響し低出生体重と成長問題を引き起こします妊娠前に父親の腸内微生物を再生することで世代間の影響を防ぐことができます

科学分野:

微生物学
生殖生物学
発達生物学

背景:

腸内微生物群は宿主のホメオスタシスと代謝ネットワークに影響を与えます
腸内微生物に影響する環境要因は,生理学的および病気に関連する反応に影響を与えます.
腸内微生物群が細菌系と子孫の健康に及ぼす影響はほとんど未知のものです

研究の目的:

世代間の健康における父親の腸内微生物の役割を調査する.
親の腸内微生物群が子孫の発達や生存に影響するかどうかを調べる
親の腸の健康と子孫の健康を結びつけるメカニズムを解明する.

主な方法:

抗生物質と剤を用いてマウスに腸内不活性化を誘導する.
子孫の出生体重,成長,死亡率の評価
レプチンのシグナル伝達,精巣の代謝産物,精子の小さなRNAを含む男性の生殖系の変化を分析する.
ディスバイオティックな父親の子孫における胎盤機能の評価

主要な成果:

父の腸内微生物の乱れは子孫の低出生体重,成長の制限,早死を引き起こした.
これらの効果は胚性線を通じて伝播され妊娠前の父親の微生物群を回復させることで救われました
父親のディズバイオシスは男性の生殖器系と精子RNAに変化をもたらした.
ディスビオティックな父親の子孫は胎内胎盤不全のリスクが高かった.

結論:

親の腸内微生物群は妊娠前の環境と世代間の健康との重要な接点として機能します
男性の"腸-生殖線軸"は,環境への曝露に敏感であり,胎盤機能に影響することで子孫の健康状態をプログラムします.
これらの発見は,父親の微生物群によって媒介される哺乳類の世代間効果の胎盤起源を明らかにしています.

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