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Updated: May 10, 2026

Generation and Recovery of β-cell Spheroids From Step-growth PEG-peptide Hydrogels
09:21

Generation and Recovery of β-cell Spheroids From Step-growth PEG-peptide Hydrogels

Published on: December 6, 2012

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精密にプログラム可能な分解と薬物の放出プロファイル トリブロックコポリエーテル水素で,割れるアセタルのペンダント

Jinsu Baek1, Nanhee Song2, Byungwoo Yoo1

  • 1Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea.

Journal of the American Chemical Society
|May 8, 2024
PubMed
まとめ

この研究では,制御された薬物投与のための新しいABA型トライブロックコポリマーヒドロゲルを導入しています. これらのヒドロゲルは,プログラム可能な分解と放出運動を提供し,現在のシステムの限界を克服します.

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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

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Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Drug Distribution: Volume of Distribution

The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.
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Physiological Pharmacokinetic Models: Assumption with Protein Binding

Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
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Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...