関連する実験動画
Updated: Aug 12, 2026

09:47
Generation of Human Alloantigen-specific T Cells from Peripheral Blood
Published on: November 21, 2014
自身免疫性甲状腺からのヒトT細胞クローン:自身免疫性甲状腺細胞の特定認識
まとめ
グレイブス病の活性化されたTリンパ球は,甲状腺細胞を認識する. 研究者はこれらのT細胞をクローン化し,自同性甲状腺細胞の特定の認識を発見し,自己免疫疾患のメカニズムに関する洞察を提供しました.
科学分野:
- 免疫学 免疫学とは
- エンドクリノロジー エンドクリノロジー
- 自己免疫疾患 自己免疫疾患
背景:
- グラブス病のような自己免疫疾患における甲状腺は,Tリンパ球に浸透していることを示している.
- 罹患腺の上皮細胞は,正常腺とは異なり,ヒト白血球抗原 (HLA) -DRを発現する.
研究 の 目的:
- グラベス病患者の甲状腺に浸透したTリンパ球をクローン化し,特徴づけること.
- これらのT細胞の特異性を理解するために,オトログの甲状腺細胞.
- ヒトの自己免疫性甲状腺疾患の研究モデルを開発する.
主な方法:
- グラブス病患者の甲状腺から侵入したT細胞のクローニングは,インタールイキン-2を用いて行われました.
- T細胞クローンの拡張.
- T細胞クローンの特異性を,甲状腺および血液細胞の自同性に対してテストする.
主要な成果:
- 3種類のT細胞クローンが特定されました.
- 1つのグループ (T4現象型) は,特異的に認識されたオトログの甲状腺細胞である.
- 別のグループ (T4現象型) は,オトログの甲状腺と血液細胞の両方を認識し,オトログの混合リンパ球反応を示した.
結論:
- クローン化されたT細胞は,ヒトの自己免疫性甲状腺疾患のモデルを提供します.
- これらのクローンの分析は,病原性のメカニズムを明らかにすることができます.
- この研究は,自己免疫疾患における望ましくない免疫反応を調節するための戦略を提供することができる.
関連する概念動画
Cell-mediated Immune Responses
Overview
Hybridoma Technology
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...

