関連する実験動画

Updated: Jun 26, 2025

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
08:05

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Published on: June 29, 2022

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Spexinはガラニン受容体2に作用することで,心房細動の脆弱性を軽減する

Desheng Li1, Yang Liu2, Changzhu Li1

  • 1National Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, International Cooperation Base for Major Cardiovascular Diseases in Cold Regions, China) College of Pharmacy (D.L., Changzhu Li, Z.Z., K.G., H.B., J.Y., K.S., L. Zhang, J.L., Chenhong Li, J.S., L. Zhao, Y.P., L.X., Y.Z., Y. Lu, B.Y., Z.P.), First Affiliated Hospital, Harbin Medical University, China.

Circulation
|May 10, 2024
PubMed
まとめ

新型リガンドであるSpexinは,GALR2受容体経由でCREBのリン酸化を阻害することで,心房細動 (AF) の感受性を低下させる. この経路は鍵となる遺伝子を抑制し AFの新たな治療標的となるのです

キーワード:
CREBIK1 についてSLN について心房細動ガランリン受容体スペキシン

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