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Updated: Jun 26, 2025

Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

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N-アセチルグルコサミンキナーズの活性とタンパク質の相互作用を調節する珍しいリン酸化モード

Arif Celik1,2, Ida Beyer1, Dorothea Fiedler1,2

  • 1Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin, Germany.

Journal of the American Chemical Society
|May 11, 2024
PubMed
まとめ

タンパク質のパイロフォスフォリレーションは,新しい改変であり,N-アセチルグルコサミンキナーゼ (NAGK) を無効化する. このピロ酸化NAGK (ppS76-NAGK) は安定し,異なるタンパク質と相互作用し,細胞シグナル伝達における新しい調節作用を示唆する.

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