ローストラル・ベントロメディアル・メドウラの脊髄発射ニューロンは,運動と交感的トーンを共調する
Zicong Zhang1, Junfeng Su1, Jing Tang1
1F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology and Ophthalmology, Harvard Medical School, Boston, MA, USA.
Cell
|May 11, 2024
まとめ
ローストラル・ベントロメディアル・メドウラ (rVMM) にある下降する脊髄発射ニューロン (SPNs) は,筋肉と交感活動を調整する. これらのSPNは,行動に不可欠な体運動機能と自律機能の両方を制御します.
科学分野:
- 神経科学
- 自律神経系
- モーター コントロール
背景:
- 調整された体機能と自律機能は 複雑な行動に不可欠です
- この協調的な行動を制御する 神経回路は まだ完全に理解されていません
研究 の 目的:
- ローストラル・ベントロメディアル・メドゥラ (rVMM) の下垂脊髄発射ニューロン (SPNs) が,体運動および交感活動の調節における役割を調査する.
- rVMM SPNがモーターと自律出力を制御するメカニズムを明らかにする.
主な方法:
- 麻酔したマウスの異なるSPN集団の光遺伝的刺激.
- アナトミック・トレーシングで SPN 内化標的を特定する.
- SPN活動と興奮状態と生理的トーンを相関させるための繊維光度測定記録
主要な成果:
- 刺激性rVMM SPNsを刺激すると,体運動と交感活動が増加し,それを抑制すると,基礎音色が低下し,運動障害が起こります.
- 抑制性rVMMSPNの光刺激により,両方の活動が低下した.
- これらのSPNは,交感性プレガンリオンニューロンと脊髄運動領域を刺激する.
- rVMM SPN活動は,異なる興奮状態における筋肉と交感性トーンと相関する.
- 阻害性rVMMSPNを静止させることで,レム睡眠中の筋肉衰弱と交感性低活性が妨げられました.
結論:
- rVMM SPNは,ソマトモーターと交感制御を統合する重要な下降経路として機能する.
- これらのニューロンは 筋肉のトーンや 交感出力や 運動やレム睡眠などの 行動状態の調節に 重要な役割を果たします
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