転移の遺伝的および非遺伝的誘導因子の相互作用を解読する
PubMedで要約を見る
まとめ
この要約は機械生成です。癌の転移を防ぐには 癌細胞がどのように 広がる能力を得るか 理解する必要があります このレビューでは 遺伝的要因と非遺伝的要因が どのように作用し,新しい検出と検知戦略を 提示しています.
科学分野
- 癌 生物学
- 分子腫瘍学
- 細胞生物学
背景
- 転移は複雑で 多段階のプロセスで ほとんどの癌による死亡の原因となります
- 有効な抗転移療法には,転移の分子誘導因子の理解が不十分である.
- 腫瘍細胞の拡散による能力の獲得は重要ですが,遺伝的および非遺伝的起源に関して議論されています.
研究 の 目的
- 転移における遺伝的および非遺伝的再プログラムイベントに関する文献をレビューする.
- 転移能力の授与における遺伝的および非遺伝的過程の相互作用について議論する.
- 治療のメカニズムを明らかにする技術的進歩を強調する.
主な方法
- 癌の転移に関する既存の科学文献のレビュー
- 遺伝的および非遺伝的再プログラムイベントの分析
- シングル・セル・マルチオミクスやバーコードなどの最近の技術進歩の議論
主要な成果
- 遺伝的変異と非遺伝的再プログラミングは 転移性能力にとって重要です
- 遺伝的および非遺伝的メカニズムは 転移のカスケード全体で協調して作用します
- 新興技術はこれらのメカニズム間の交互を研究する新しい方法を提供します.
結論
- 遺伝的および非遺伝的要因の組み合わせの役割を理解することは,転移と闘うための鍵です.
- 早期発見と中断のための革新的な治療戦略を開発することができます.
- 単細胞マルチオミクスとバーコードは転移メカニズムの研究を進めるでしょう.
関連する概念動画
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

