関連する実験動画

Updated: Jun 25, 2025

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

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リガンド結合は単一分子インテグリン構成活性化を開始する

Jing Li1, Myung Hyun Jo2, Jiabin Yan3

  • 1Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|May 21, 2024
PubMed
まとめ

インテグリン活性化は,リガンド結合時に外からの信号で始まり,その後に内からの信号が付きます. アクチン細胞骨格を通る牽引力の伝達は,完全なインテグリン活性化に不可欠である.

キーワード:
FRET について中から外へのシグナリングインテグリン活性化経路整体構造の変化インテグリン構造動態リガンド外から入るシグナル単一の分子タリン

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