関連する実験動画

Updated: Jun 24, 2025

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
11:21

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

694

POT1は,ヒトのテロメアにおけるCST-Polα/プリマースを勧誘し,調節する

Sarah W Cai1, Hiroyuki Takai2, Arthur J Zaug3

  • 1Laboratory of Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA; Laboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY 10065, USA.

Cell
|June 5, 2024
PubMed
まとめ

テロメア複製にはCtc1/Stn1/Ten1 (CST) コンプレックスが必要です. リン酸化POT1はCSTをテロメアに誘導し,テロメラーゼがG豊富な鎖を拡張し,CSTがC豊富な鎖の合成を完了するまで不活性にします.

キーワード:
CST についてDNA複製DNA-タンパク質複合体POT1 についてクリオ・エムエンド・レプリケーション問題リン酸調節ポリメラーゼ α/プリマゼシェルテリンテロメア

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