関連する実験動画

Updated: Jun 24, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

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ヒトのγ-分泌酵素による基板認識と分裂の分子機構

Xuefei Guo1, Haotian Li1, Chuangye Yan1

  • 1Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, Key Laboratory for Protein Sciences of Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Science (New York, N.Y.)
|June 6, 2024
PubMed
まとめ

この研究は,α-セクレターゼ処理アミロイド前駆体タンパク質C末端断片 (APP-C99) とその裂解産物の原子構造を明らかにする. この発見は,アミロイドβペプチド生成の段階的なメカニズムを明らかにする.

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