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Updated: Jun 24, 2025

Measurements of Physiological Stress Responses in C. Elegans
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Published on: May 21, 2020

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リボ毒性ストレス反応は紫外線による細胞死を引き起こす

Niladri K Sinha1, Connor McKenney2, Zhong Y Yeow3

  • 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Cell
|June 6, 2024
PubMed
まとめ

紫外線はRNAを損傷し,ZAKキナーゼ経由でアポトーシスを誘発するリボ毒性ストレス反応 (RSR) を引き起こすが,DNA損傷反応 (DDR) は誘発しない. ネガティブなフィードバックはZAKを調節し 核酸の損傷を防ぎます

キーワード:
DNA 損傷反応GCN2 について紫外線ZAKアポトーシス衝突するフォスフォプロテオミックリボソームリボ毒性ストレスシグナリング

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