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Updated: Jun 24, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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脳の細胞内の細胞外タンパク質の標的分解とトランサイトシスを誘発する二機能分子

Rebecca A Howell1, Shikun Wang1, Mihir Khambete1

  • 1Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States.

Journal of the American Chemical Society
|June 10, 2024
PubMed
まとめ

新しいTransMoDEsの分子は血脳障壁を通過して,中枢神経系内の標的タンパク質を分解します. この標的型タンパク質分解 (TPD) のアプローチは,神経疾患に対する新しい治療戦略を提供します.

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