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Updated: Jun 24, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

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肥満はマクロファージにPD-1を誘導し,抗腫瘍免疫を抑制する

Jackie E Bader1, Melissa M Wolf1, Gian Luca Lupica-Tondo1

  • 1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Nature
|June 12, 2024
PubMed
まとめ

肥満は腫瘍関連マクロファージ (TAMs) のPD-1発現を誘導し,抗腫瘍免疫を低下させる. PD- 1を阻害すると,マクロファージの代謝とT細胞の活性化が促進され,肥満患者のがん免疫療法への反応が改善されます.

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