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Updated: Jul 6, 2026

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G Stefano Brigidi, Michael G B Hayes, Nathaniel P Delos Santos

    Cell
    |June 13, 2024
    PubMed
    まとめ

    No abstract available in PubMed .

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    Nonsense-mediated mRNA Decay02:27

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    The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
    Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...