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Updated: Jun 23, 2025

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STINGは多発性硬化症における神経の炎症的ストレス反応を指揮する

Marcel S Woo1, Christina Mayer1, Lars Binkle-Ladisch1

  • 1Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Cell
|June 15, 2024
PubMed
まとめ

神経細胞は,炎症とグルタミン酸興奮毒性に対する反応としてSTINGを活性化させ,多発性硬化症 (MS) のフェロプトーシスと神経変異を引き起こす. ニューロンのSTINGを標的にすることで MSの神経変性に対する 治療の可能性が生まれます

キーワード:
スティングカルシウム信号細胞死興奮毒性フェロプトーシス多発性硬化症神経変性神経炎症

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