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Updated: May 5, 2026

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

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がん免疫療法の結果に関連する腸内微生物群の生態学的トポロジーに基づくカスタムスコアリング

Lisa Derosa1, Valerio Iebba2, Carolina Alves Costa Silva3

  • 1Gustave Roussy Cancer Campus, ClinicObiome, Villejuif, France; Université Paris-Saclay, Ile-de-France, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France; Department of Medical Oncology, Gustave Roussy, Villejuif, France.

Cell
|June 21, 2024
PubMed
まとめ

研究者は,免疫チェックポイント阻害剤 (ICI) を投与しているがん患者の腸内不活性化を評価するための新しいスコアリングシステムを開発した. このツールは治療への反応を予測し,より良い結果を出すために個別化された微生物群の介入を導くのに役立ちます.

キーワード:
アッカーマンシア・ムチニフィラPD-(L) 1 についてトポスコアバイオマーカー癌について腸内微生物群免疫チェックポイントの封鎖免疫療法メタゲノミクス微生物群

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
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