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Updated: Jun 23, 2025

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

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代替ポリアデニレーションレギュレータの複合単細胞特性

Madeline H Kowalski1, Hans-Hermann Wessels2, Johannes Linder3

  • 1New York Genome Center, New York, NY, USA; Center for Genomics and Systems Biology, New York University, New York, NY, USA; New York University Grossman School of Medicine, New York, NY, USA.

Cell
|June 26, 2024
PubMed
まとめ

この研究では,CPAとポリアデニレーション (CPA) タンパク質が遺伝子発現の多様性を制御する方法をマッピングするためにCPA-Perturb-seqを導入します. この発見は,RNA処理因子によるポリA部位の調整を明らかにし,転写後の調節に関する理解を深めています.

キーワード:
パートルブ=セクRNA 処理代替ポリアデニレーション分裂とポリアデニレーショントランスクリプション後の調節

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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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