亜鉛は,転写因子フィラメントによる窒素固定の制御を媒介する
Jieshun Lin1, Peter K Bjørk2, Marie V Kolte2
1Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. jslin@mbg.au.dk.
Nature
|June 26, 2024
まとめ
亜鉛は豆類の根の結節に伝達物質として作用し,窒素の固定を制御する. 土壌の窒素濃度が高いと 亜鉛が低下し 変化する条件に適応するために 結節を分解するレギュレータが活性化します
科学分野:
- 植物生物学
- 分子生物学
- 生物化学
背景:
- 植物は代謝と遺伝子発現の調整によって 環境の変化に適応する.
- 豆類は,土壌の窒素吸収と共生的な窒素固定のバランスをとって窒素ホメオスタシスを維持します.
- 根のノードルには 豆類の窒素固定に不可欠な共生細菌があります
研究 の 目的:
- 豆類の根の結節における細胞内第2伝達物質としての亜鉛の役割を調査する.
- 環境信号をノードル内の代謝制御に接続する分子機構を特定する.
- 植物がノードル機能を 土壌の窒素濃度の変化に適応させる方法を理解する.
主な方法:
- 新しい転写調節剤の特定,窒素下固定 (FUN).
- 非活性状態から活性状態へのFUNの移行を制御する亜鉛の役割の分析
- FUNがノードル分解に 関わる経路を 直接標的にすることを調査しています
主要な成果:
- 亜鉛は第二のメッセンジャーとして働き,環境のシグナルをノードル代謝の転写調節と結びつける.
- 高濃度の土壌窒素によって誘発される低濃度の亜鉛は,FUNを活性化します.
- 活性化されたFUNは複数の経路をターゲットにすることで結節の分解を開始します.
結論:
- 亜鉛依存のフィラメント化メカニズムにより,ノドルは環境中の窒素の利用可能性に基づいて機能を適応させることができます.
- 金属イオンは環境信号と 植物の発達を統合する上で 重要な役割を果たします
- この発見は,豆類の作物の窒素固定を最適化するための意味を持つ.
関連する概念動画
The Roles of Bacteria and Fungi in Plant Nutrition
35.2K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
35.2K
Key Elements for Plant Nutrition
18.7K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
18.7K
Overview of Nitrogen Metabolism
7.9K
Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of ammonia, ammonium ions, nitrate, nitrite, or nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
7.9K
Generation of Straight or Branched Actin Filaments
2.9K
The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
2.9K
Formation of Intermediate Filaments
3.0K
Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two cytoskeletal proteins, intermediate filament formation lacks the enzymatic activity to hydrolyze nucleotides like ATP and GTP to generate energy for polymerization. Therefore, the formation of intermediate filaments is multistep self-assembly. The involvement of any accessory proteins in intermediate filament formation has not yet been...
3.0K
Combinatorial Gene Control
8.3K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.3K


