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Updated: Aug 8, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

アミノ酸の置換剤は,酵素における大規模なポリペプチドの欠損を補償する

C Ho, M Jasin, P Schimmel

    Science (New York, N.Y.)
    |July 26, 1985
    PubMed
    まとめ

    酵素工学は,特定の変異を用いて,大規模な削除で失われた活性を再生することができます. これらのタンパク質設計戦略は,触媒機能を大幅に強化し,欠落した配列の補償さえします.

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    Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability10:31

    Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

    Published on: February 3, 2022

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