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Updated: Jun 22, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

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構造情報型言語モデルによるタンパク質と抗体複合体の無監督進化

Varun R Shanker1,2,3, Theodora U J Bruun2,3,4, Brian L Hie3,4

  • 1Stanford Biophysics Program, Stanford University School of Medicine, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|July 4, 2024
PubMed
まとめ

タンパク質の構造を言語モデルに統合することで タンパク質の設計と進化が促進されます このアプローチは,SARS-CoV-2の変種に対する抗体治療を改善し,タンパク質工学の強力な方法を示した.

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Protein Organization01:24

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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Antibody Structure and Classes

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The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
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